ArthroConcept

Quellen

Literatur für den Gelenk Kompass

Zusammenfassende, von Experten geprüfte Informationen finden Sie unter www.qkg-gesellschaft.de. Der Test basiert primär auf den dort bereitgestellten Informationen und Studien. Zusätzlich fließen eigene Erfahrungen von Mediziner:innen und weiteren Experten aus der Gesundheitsbranche sowie aus unserem persönlichen Netzwerk in die Gestaltung des Tests ein. Der Test soll regelmäßig weiterentwickelt und angepasst werden. Des Weiteren wurden folgende Studien verwendet:

Bewegung

  1. Bricca, A., Juhl, C. B., Steultjens, M., Wirth, W., & Roos, E. M. (2019). Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: A systematic review of randomised controlled trials. British Journal of Sports Medicine, 53(15), 940–947. https://doi.org/10.1136/bjsports-2017-098661

  2. Bull, F. C., Al-Ansari, S. S., Biddle, S., Borodulin, K., Buman, M. P., Cardon, G., Carty, C., Chaput, J.-P., Chastin, S., Chou, R., Dempsey, P. C., DiPietro, L., Ekelund, U., Firth, J., Friedenreich, C. M., Garcia, L., Gichu, M., Jago, R., Katzmarzyk, P. T., … Willumsen, J. F. (2020). World Health Organization 2020 guidelines on physical activity and sedentary behaviour. British Journal of Sports Medicine, 54(24), 1451–1462. https://doi.org/10.1136/bjsports-2020-102955

  3. Bull, F. C., Maslin, T. S., & Armstrong, T. (2009). Global Physical Activity Questionnaire (GPAQ): Nine country reliability and validity study. Journal of Physical Activity and Health, 6(6), 790–804. https://doi.org/10.1123/jpah.6.6.790

  4. Coburn, S. L., Crossley, K. M., Kemp, J. L., et al. (2023). Immediate and delayed effects of joint loading activities on knee and hip cartilage: A systematic review and meta-analysis. Sports Medicine - Open, 9, 56. https://doi.org/10.1186/s40798-023-00602-7

  5. Craig, C. L., Marshall, A. L., Sjöström, M., Bauman, A. E., Booth, M. L., Ainsworth, B. E., Pratt, M., Ekelund, U., Yngve, A., Sallis, J. F., & Oja, P. (2003). International Physical Activity Questionnaire: 12-country reliability and validity. Medicine & Science in Sports & Exercise, 35(8), 1381–1395. https://doi.org/10.1249/01.MSS.0000078924.61453.FB

  6. Dunstan, D. W., Kingwell, B. A., Larsen, R., Healy, G. N., Cerin, E., Hamilton, M. T., Shaw, J. E., Bertovic, D. A., Zimmet, P. Z., Salmon, J., & Owen, N. (2012). Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care, 35(5), 976–983. https://doi.org/10.2337/dc11-1931

  7. Ekelund, U., Steene-Johannessen, J., Brown, W. J., Fagerland, M. W., Owen, N., Powell, K. E., Bauman, A., & Lee, I.-M. (2016). Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women. The Lancet, 388(10051), 1302–1310. https://doi.org/10.1016/S0140-6736(16)30370-1

  8. Ettinger, W. H., Jr., Burns, R., Messier, S. P., Applegate, W., Rejeski, W. J., Morgan, T., Shumaker, S., Berry, M. J., O’Toole, M., Monu, J., & Craven, T. (1997). A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. JAMA, 277(1), 25–31. https://doi.org/10.1001/jama.1997.03540250033028

  9. Fransen, M., McConnell, S., Harmer, A. R., Van der Esch, M., Simic, M., & Bennell, K. L. (2015). Exercise for osteoarthritis of the knee. Cochrane Database of Systematic Reviews, (1), CD004376. https://doi.org/10.1002/14651858.CD004376.pub3

  10. Fransen, M., McConnell, S., Hernandez-Molina, G., & Reichenbach, S. (2014). Exercise for osteoarthritis of the hip. Cochrane Database of Systematic Reviews, (4), CD007912. https://doi.org/10.1002/14651858.CD007912.pub2

  11. Haber, T., Lawford, B. J., Bennell, K., Holden, M., White, D. K., & Hinman, R. S. (2025). Recent highlights and uncertainties in exercise management of knee osteoarthritis. Journal of Physiotherapy, 71(3), 158–166. https://doi.org/10.1016/j.jphys.2025.06.010

  12. Henriksen, M., Runhaar, J., Turkiewicz, A., & Englund, M. (2024). Exercise for knee osteoarthritis pain: Association or causation? Osteoarthritis and Cartilage, 32(6), 643–648. https://doi.org/10.1016/j.joca.2024.03.001

  13. Hurley, M., Dickson, K., Hallett, R., Grant, R., Hauari, H., Walsh, N., Stansfield, C., & Oliver, S. (2018). Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: A mixed methods review. Cochrane Database of Systematic Reviews, (4), CD010842. https://doi.org/10.1002/14651858.CD010842.pub2

  14. Júdice, P. B., Rosa, G. B., Magalhães, J. P., Hetherington-Rauth, M., Correia, I. R., & Sardinha, L. B. (2021). Criterion validity of a single-item question for assessment of daily breaks in sedentary time in adults. European Journal of Public Health, 31(5), 1048–1053. https://doi.org/10.1093/eurpub/ckab030

  15. Juhl, C., Christensen, R., Roos, E. M., Zhang, W., & Lund, H. (2014). Impact of exercise type and dose on pain and disability in knee osteoarthritis: A systematic review and meta-regression analysis of randomized controlled trials. Arthritis & Rheumatology, 66(3), 622–636. https://doi.org/10.1002/art.38290

  16. Lee, J., Chang, R. W., Ehrlich-Jones, L., Kwoh, C. K., Nevitt, M., Semanik, P. A., Sharma, L., Sohn, M.-W., Song, J., & Dunlop, D. D. (2015). Sedentary behavior and physical function: Objective evidence from the Osteoarthritis Initiative. Arthritis Care & Research, 67(3), 366–373. https://doi.org/10.1002/acr.22432

  17. Li, Y., Su, Y., Chen, S., et al. (2016). The effects of resistance exercise in patients with knee osteoarthritis: A systematic review and meta-analysis. Clinical Rehabilitation, 30(10), 947–959. https://doi.org/10.1177/0269215515610039

  18. Lim, J., Choi, A., & Kim, B. (2024). The effects of resistance training on pain, strength, and function in osteoarthritis: Systematic review and meta-analysis. Journal of Personalized Medicine, 14(12), 1130. https://doi.org/10.3390/jpm14121130

  19. Messier, S. P., Mihalko, S. L., Legault, C., et al. (2013). Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: The IDEA randomized clinical trial. JAMA, 310(12), 1263–1273. https://doi.org/10.1001/jama.2013.277669

  20. Roddy, E., Zhang, W., & Doherty, M. (2005). Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review. Annals of the Rheumatic Diseases, 64(4), 544–548. https://doi.org/10.1136/ard.2004.028746

Ernährung

  1. Asadi, S., Grafenauer, S., Burley, C. V., Fitzgerald, C., Humburg, P., & Parmenter, B. J. (2025). The effectiveness of dietary intervention in osteoarthritis management: A systematic review and meta-analysis of randomized clinical trials. European Journal of Clinical Nutrition, 79(10), 959–971. https://doi.org/10.1038/s41430-025-01622-0

  2. Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., Visvanathan, R., Volpi, E., & Boirie, Y. (2013). Evidence-based recommendations for optimal dietary protein intake in older people: A position paper from the PROT-AGE Study Group. Journal of the American Medical Directors Association, 14(8), 542–559. https://doi.org/10.1016/j.jamda.2013.05.021

  3. Christensen, R., Astrup, A., & Bliddal, H. (2005). Weight loss: The treatment of choice for knee osteoarthritis? A randomized trial. Osteoarthritis and Cartilage, 13(1), 20–27. https://doi.org/10.1016/j.joca.2004.10.008

  4. Christensen, R., Bartels, E. M., Astrup, A., & Bliddal, H. (2007). Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: A systematic review and meta-analysis. Annals of the Rheumatic Diseases, 66(4), 433–439. https://doi.org/10.1136/ard.2006.065904

  5. Deutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., Singer, P., Teta, D., Tipton, K., & Calder, P. C. (2014). Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group. Clinical Nutrition, 33(6), 929–936. https://doi.org/10.1016/j.clnu.2014.04.007

  6. Elma, Ö., Yilmaz, S. T., Deliens, T., et al. (2020). Do nutritional factors interact with chronic musculoskeletal pain? A systematic review. Journal of Clinical Medicine, 9(3), 702. https://doi.org/10.3390/jcm9030702

  7. Hall, K. D., Ayuketah, A., Brychta, R., Cai, H., Cassimatis, T., Chen, K. Y., Chung, S. T., Costa, E., Courville, A., Darcey, V., Fletcher, L. A., Forde, C. G., Gharib, A. M., Guo, J., Howard, R., Joseph, P. V., McGehee, S., Ouwerkerk, R., Raisinger, K., … Zhou, M. (2019). Ultra-processed diets cause excess calorie intake and weight gain: An inpatient randomized controlled trial of ad libitum food intake. Cell Metabolism, 30(1), 67–77.e3. https://doi.org/10.1016/j.cmet.2019.05.008

  8. Mamerow, M. M., Mettler, J. A., English, K. L., Casperson, S. L., Arentson-Lantz, E., Sheffield-Moore, M., Layman, D. K., & Paddon-Jones, D. (2014). Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. The Journal of Nutrition, 144(6), 876–880. https://doi.org/10.3945/jn.113.185280

  9. Martínez-González, M. A., Corella, D., Salas-Salvadó, J., et al. (2012). Cohort profile: Design and methods of the PREDIMED study. International Journal of Epidemiology, 41(2), 377–385. https://doi.org/10.1093/ije/dyq250

  10. Messier, S. P., Resnik, A. E., Beavers, D. P., et al. (2018). Intentional weight loss in overweight and obese patients with knee osteoarthritis: Is more better? Arthritis Care & Research, 70(11), 1569–1575. https://doi.org/10.1002/acr.23608

  11. Morales-Ivorra, I., Romera-Baures, M., Roman-Viñas, B., & Serra-Majem, L. (2018). Osteoarthritis and the Mediterranean diet: A systematic review. Nutrients, 10(8), 1030. https://doi.org/10.3390/nu10081030

  12. Schwingshackl, L., Schwedhelm, C., Hoffmann, G., et al. (2018). Food groups and risk of all-cause mortality: A systematic review and meta-analysis of prospective studies. The American Journal of Clinical Nutrition, 105(6), 1462–1473. https://doi.org/10.3945/ajcn.117.153148

  13. Institutionelle Ernährungsgrundlagen

  14. Deutsche Gesellschaft für Ernährung e. V. (2024). Gut essen und trinken – die DGE-Empfehlungen. https://www.dge.de/gesunde-ernaehrung/gut-essen-und-trinken/dge-empfehlungen/

  15. Deutsche Gesellschaft für Ernährung e. V. (2025). Referenzwerte für die Nährstoffzufuhr: Protein. https://www.dge.de/wissenschaft/referenzwerte/protein/

Nahrungsergänzungsmittel

  1. Bannuru, R. R., Osani, M. C., Al-Eid, F., & Wang, C. (2018). Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis. Seminars in Arthritis and Rheumatism, 48(3), 416–429. https://doi.org/10.1016/j.semarthrit.2018.03.001

  2. Bartels, E. M., Folmer, V. N., Bliddal, H., Altman, R. D., Juhl, C., Tarp, S., Zhang, W., & Christensen, R. (2015). Efficacy and safety of ginger in osteoarthritis patients: A meta-analysis of randomized placebo-controlled trials. Osteoarthritis and Cartilage, 23(1), 13–21. https://doi.org/10.1016/j.joca.2014.09.024

  3. Benito-Ruiz, P., Camacho-Zambrano, M. M., Carrillo-Arcentales, J. N., Mestanza-Peralta, M. A., Vallejo-Flores, C. A., Vargas-López, S. V., Villacís-Tamayo, R. A., & Zurita-Gavilanes, L. A. (2009). A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60(Suppl. 2), 99–113. https://doi.org/10.1080/09637480802498820

  4. Bislev, L. S., Grove-Laugesen, D., & Rejnmark, L. (2021). Vitamin D and muscle health: A systematic review and meta-analysis of randomized placebo-controlled trials. Journal of Bone and Mineral Research, 36(9), 1651–1660. https://doi.org/10.1002/jbmr.4412

  5. Black, C., Clar, C., Henderson, R., MacEachern, C., McNamee, P., Quayyum, Z., Royle, P., & Thomas, S. (2009). The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: A systematic review and economic evaluation. Health Technology Assessment, 13(52). https://doi.org/10.3310/hta13520

  6. Brien, S., Prescott, P., Bashir, N., Lewith, H., & Lewith, G. (2008). Systematic review of the nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis. Osteoarthritis and Cartilage, 16(11), 1277–1288. https://doi.org/10.1016/j.joca.2008.03.002

  7. Cameron, M., & Chrubasik, S. (2014). Oral herbal therapies for treating osteoarthritis. Cochrane Database of Systematic Reviews, 2014(5), Article CD002947. https://doi.org/10.1002/14651858.CD002947.pub2

  8. Clegg, D. O., Reda, D. J., Harris, C. L., et al. (2006). Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. The New England Journal of Medicine, 354(8), 795–808. https://doi.org/10.1056/NEJMoa052771

  9. Cordingley, D. M., & Cornish, S. M. (2022). Omega-3 fatty acids for the management of osteoarthritis: A narrative review. Nutrients, 14(16), 3362. https://doi.org/10.3390/nu14163362

  10. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., & Raychaudhuri, S. P. (2009). Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: A clinical trial. International Journal of Medical Sciences, 6(6), 312–321. https://doi.org/10.7150/ijms.6.312

  11. Debbi, E. M., Agar, G., Fichman, G., Ziv, Y. B., Kardosh, R., Halperin, N., Elbaz, A., & Beer, Y. (2011). Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: A randomized controlled study. BMC Complementary and Alternative Medicine, 11, 50. https://doi.org/10.1186/1472-6882-11-50

  12. Deng, W., Yi, Z., Yin, E., Lu, R., You, H., & Yuan, X. (2023). Effect of omega-3 polyunsaturated fatty acids supplementation for patients with osteoarthritis: A meta-analysis. Journal of Orthopaedic Surgery and Research, 18, 381. https://doi.org/10.1186/s13018-023-03855-w

  13. Dubey, V., Kheni, D., & Sureja, V. (2024). Efficacy evaluation of standardized Boswellia serrata extract (Aflapin®) in osteoarthritis: A systematic review and sub-group meta-analysis study. EXPLORE, 20(5), Article 102983. https://doi.org/10.1016/j.explore.2024.02.001

  14. EFSA. (2009). EFSA Journal, 7(9), 1220. https://doi.org/10.2903/j.efsa.2009.1220

  15. EFSA. (2009). EFSA Journal, 7(9), 1226. https://doi.org/10.2903/j.efsa.2009.1226

  16. EFSA. (2009). EFSA Journal, 7(9), 1228. https://doi.org/10.2903/j.efsa.2009.1228

  17. EFSA. (2010). EFSA Journal, 8(10), 1808. https://doi.org/10.2903/j.efsa.2010.1808

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  20. Gao, X.-R., Chen, Y.-S., & Deng, W. (2017). The effect of vitamin D supplementation on knee osteoarthritis: A meta-analysis of randomized controlled trials. International Journal of Surgery, 46, 14–20. https://doi.org/10.1016/j.ijsu.2017.08.010

  21. Heidari-Beni, M., Moravejolahkami, A. R., Gorgian, P., Askari, G., Tarrahi, M. J., & Bahreini-Esfahani, N. (2020). Herbal formulation “turmeric extract, black pepper, and ginger” versus naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial. Phytotherapy Research, 34(8), 2067–2073. https://doi.org/10.1002/ptr.6671

  22. Hill, C. L., March, L. M., Aitken, D., et al. (2016). Fish oil in knee osteoarthritis: A randomised clinical trial of low dose versus high dose. Annals of the Rheumatic Diseases, 75(1), 23–29. https://doi.org/10.1136/annrheumdis-2014-207169

  23. Inprasit, C., Bunyamahote, S., Boonpattharatthiti, K., Thimkorn, P., Intakhiao, S., & Dhippayom, T. (2026). Evaluating the efficacy and safety of Curcuma longa, Boswellia serrata, and their mixed formulation in treating knee osteoarthritis: A systematic review and network meta-analysis. Complementary Therapies in Medicine, 96, Article 103256. https://doi.org/10.1016/j.ctim.2025.103256

  24. Jin, X., Jones, G., Cicuttini, F., et al. (2016). Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: A randomized clinical trial. JAMA, 315(10), 1005–1013. https://doi.org/10.1001/jama.2016.1961

  25. Karlapudi, V., Sunkara, K. B., Konda, P. R., Sarma, K. V., & Rokkam, M. P. (2023). Efficacy and safety of Aflapin®, a novel Boswellia serrata extract, in the treatment of osteoarthritis of the knee: A short-term 30-day randomized, double-blind, placebo-controlled clinical study. Journal of the American Nutrition Association, 42(2), 159–168. https://doi.org/10.1080/07315724.2021.2014370

  26. Knudsen, J. F., & Sokol, G. H. (2008). Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy, 28(4), 540–548. https://doi.org/10.1592/phco.28.4.540

  27. Kumar, B., Ghaytidak, A. B., Pandey, A. K., Somepalli, R. R., Sarda, P., Raychaudhuri, S. P., & Rokkam, M. P. (2025). A standardized Boswellia serrata extract improves knee joint function and cartilage morphology in human volunteers with mild to moderate osteoarthritis in a randomized placebo-controlled study. Journal of the American Nutrition Association, 44(5), 375–386. https://doi.org/10.1080/27697061.2024.2438894

  28. Laslett, L. L., Scheepers, L. E. J. M., Antony, B., et al. (2024). Krill oil for knee osteoarthritis: A randomized clinical trial. JAMA, 331(23), 1997–2006. https://doi.org/10.1001/jama.2024.6063

  29. Lugo, J. P., Saiyed, Z. M., & Lane, N. E. (2016). Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: A multicenter randomized, double-blind, placebo-controlled study. Nutrition Journal, 15, 14. https://doi.org/10.1186/s12937-016-0130-8

  30. MacFarlane, L. A., Cook, N. R., Kim, E., et al. (2020). The effects of vitamin D and marine omega-3 fatty acid supplementation on chronic knee pain in older US adults. Arthritis & Rheumatology, 72(11), 1836–1844. https://doi.org/10.1002/art.41416

  31. McAlindon, T., LaValley, M., Schneider, E., et al. (2013). Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: A randomized controlled trial. JAMA, 309(2), 155–162. https://doi.org/10.1001/jama.2012.164487

  32. McGlory, C., Gorissen, S. H. M., Kamal, M., Bahniwal, R., Hector, A. J., Baker, S. K., Chabowski, A., & Phillips, S. M. (2019). Omega-3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobilization in healthy young women. The FASEB Journal, 33(3), 4586–4597. https://doi.org/10.1096/fj.201801857RRR

  33. Miotto, P. M., McGlory, C., Bahniwal, R., Kamal, M., Phillips, S. M., & Holloway, G. P. (2019). Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. The FASEB Journal, 33(7), 8232–8240. https://doi.org/10.1096/fj.201900095R

  34. National Institutes of Health, Office of Dietary Supplements. (n.d.). Zinc: Fact sheet for health professionals. https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/

  35. Paultre, K., Cade, W., Hernandez, D., Reynolds, J., Greif, D., & Best, T. M. (2021). Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: A systematic review. BMJ Open Sport & Exercise Medicine, 7(1), e000935. https://doi.org/10.1136/bmjsem-2020-000935

  36. Prokopidis, K., Giannos, P., Katsikas Triantafyllidis, K., Kechagias, K. S., Mesinovic, J., Witard, O. C., & Scott, D. (2022). Effect of vitamin D monotherapy on indices of sarcopenia in community-dwelling older adults: A systematic review and meta-analysis. Journal of Cachexia, Sarcopenia and Muscle, 13(3), 1642–1652. https://doi.org/10.1002/jcsm.12976

  37. Sengupta, K., Krishnaraju, A. V., Vishal, A. A., Mishra, A., Trimurtulu, G., Sarma, K. V. S., Raychaudhuri, S. K., & Raychaudhuri, S. P. (2010). Comparative efficacy and tolerability of 5-Loxin® and Aflapin® against osteoarthritis of the knee: A double blind, randomized, placebo controlled clinical study. International Journal of Medical Sciences, 7(6), 366–377. https://doi.org/10.7150/ijms.7.366

  38. Simental-Mendía, M., Sánchez-García, A., Vilchez-Cavazos, F., Acosta-Olivo, C. A., Peña-Martínez, V. M., & Simental-Mendía, L. E. (2018). Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: A systematic review and meta-analysis of randomized placebo-controlled trials. Rheumatology International, 38(8), 1413–1428. https://doi.org/10.1007/s00296-018-4077-2

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  40. Vishal, A. A., Mishra, A., & Raychaudhuri, S. P. (2011). A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of Aflapin® in subjects with osteoarthritis of knee. International Journal of Medical Sciences, 8(7), 615–622. https://doi.org/10.7150/ijms.8.615

  41. Wandel, S., Jüni, P., Tendal, B., Nüesch, E., Villiger, P. M., Welton, N. J., Reichenbach, S., & Trelle, S. (2010). Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: Network meta-analysis. BMJ, 341, c4675. https://doi.org/10.1136/bmj.c4675

  42. Wang, R., Wang, Z., Xiang, S., Jin, Z., Zhang, J., Zeng, J., Tong, P., & Lv, S. (2023). Relationship between 25-hydroxy vitamin D and knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. Frontiers in Medicine, 10, 1200592. https://doi.org/10.3389/fmed.2023.1200592

  43. Yu, G., Xiang, W., Zhang, T., Zeng, L., Yang, K., & Li, J. (2020). Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: A systematic review and meta-analysis. BMC Complementary Medicine and Therapies, 20, 225. https://doi.org/10.1186/s12906-020-02985-6

  44. Zdzieblik, D., Brame, J., Oesser, S., Gollhofer, A., & König, D. (2021). The influence of specific bioactive collagen peptides on knee joint discomfort in young physically active adults: A randomized controlled trial. Nutrients, 13(2), 523. https://doi.org/10.3390/nu13020523

Hilfsmittel und sonstige Therapien

  1. Abdel-Aal, N. M., Ibrahim, A. H., Kotb, M. M., Hussein, A. A., & Hussein, H. M. (2022). Mechanical traction from different knee joint angles in patients with knee osteoarthritis: A randomized controlled trial. Clinical Rehabilitation, 36(8), 1083–1096. https://doi.org/10.1177/02692155221091508

  2. Albano, L. (2017). Innovative application of Cox Flexion Distraction Decompression to the knee: A retrospective case series. The Journal of the Canadian Chiropractic Association, 61(2), 153–161. https://pmc.ncbi.nlm.nih.gov/articles/PMC5596966/

  3. Alpayci, M., Ozkan, Y., Yazmalar, L., Hiz, O., & Ediz, L. (2013). A randomized controlled trial on the efficacy of intermittent and continuous traction for patients with knee osteoarthritis. Clinical Rehabilitation, 27(4), 347–354. https://doi.org/10.1177/0269215512459062

  4. Chen, Y., Sun, Y., Pan, X., Ho, K., & Li, G. (2015). Joint distraction attenuates osteoarthritis by reducing secondary inflammation, cartilage degeneration and subchondral bone aberrant change. Osteoarthritis and Cartilage, 23(10), 1728–1735. https://doi.org/10.1016/j.joca.2015.05.018

    Einordnung: Präklinischer Tierversuch am Rattenmodell; Distraktion mittels externem Fixateur, kein klinischer Wirksamkeitsnachweis am Menschen.

  5. Cudejko, T., van der Esch, M., van der Leeden, M., Roorda, L. D., Pallari, J., Bennell, K. L., Lund, H., & Dekker, J. (2018). Effect of soft braces on pain and physical function in patients with knee osteoarthritis: Systematic review with meta-analyses. Archives of Physical Medicine and Rehabilitation, 99(1), 153–163. https://doi.org/10.1016/j.apmr.2017.04.029

  6. Cudejko, T., van der Esch, M., van den Noort, J. C., et al. (2017). The immediate effect of a soft knee brace on pain, activity limitations, self-reported knee instability, and self-reported knee confidence in patients with knee osteoarthritis. Arthritis Research & Therapy, 19, 260. https://doi.org/10.1186/s13075-017-1456-0

  7. Florjančič, K., & Vauhnik, R. (2025). Effects of standard physiotherapy with the addition of mechanical traction on pain, physical activity and quality of life in patients with knee osteoarthritis. Medicina, 61(3), Article 507. https://doi.org/10.3390/medicina61030507

  8. Guillot, X., Tordi, N., Prati, C., et al. (2019). Local ice cryotherapy decreases synovial interleukin-6, interleukin-1β, VEGF, prostaglandin-E2 and NF-κB p65 in human knee arthritis: A controlled study. Arthritis Research & Therapy, 21, 180. https://doi.org/10.1186/s13075-019-1965-0

  9. Guillot, X., Tordi, N., Prati, C., Verhoeven, F., Pazart, L., & Wendling, D. (2017). Cryotherapy decreases synovial Doppler activity and pain in knee arthritis: A randomized-controlled trial. Joint Bone Spine, 84(4), 477–483. https://doi.org/10.1016/j.jbspin.2016.09.004

  10. Jansen, M. P., Mastbergen, S. C., MacKay, J. W., Turmezei, T. D., & Lafeber, F. (2022). Knee joint distraction results in MRI cartilage thickness increase up to 10 years after treatment. Rheumatology, 61(3), 974–982. https://doi.org/10.1093/rheumatology/keab456

    Einordnung: Langzeitbeobachtung nach operativer Kniegelenkdistraktion; nicht mit nichtinvasiver Traktion gleichzusetzen. Online-Veröffentlichung 2021, Jahrgang 2022.

  11. Khademi-Kalantari, K., Mahmoodi Aghdam, S., Akbarzadeh Baghban, A., Rezayi, M., Rahimi, A., & Naimee, S. (2014). Effects of non-surgical joint distraction in the treatment of severe knee osteoarthritis. Journal of Bodywork and Movement Therapies, 18(4), 533–539. https://doi.org/10.1016/j.jbmt.2013.12.001

  12. Kwon, H. J., Kim, C. S., Kim, D. H., Shin, J. W., Choi, D., & Choi, S. S. (2024). Effectiveness of cooled radiofrequency ablation of genicular nerves in patients with chronic knee pain due to osteoarthritis: A double-blind, randomized, controlled study. Medicina, 60(6), 857. https://doi.org/10.3390/medicina60060857

  13. Lyman, J., Khalouf, F., Zora, K., DePalma, M., Loudermilk, E., Guirguis, M., Beall, D., Kohan, L., & Chen, A. F. (2022). Cooled radiofrequency ablation of genicular nerves provides 24-month durability in the management of osteoarthritic knee pain. Pain Practice. https://doi.org/10.1111/papr.13139

  14. Mahler, E. A. M., Minten, M. J. M., Leseman-Hoogenboom, M. M., et al. (2019). Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis: A randomised, double-blinded, sham-controlled trial. Annals of the Rheumatic Diseases, 78(1), 83–90. https://doi.org/10.1136/annrheumdis-2018-214104

  15. Runge, N., Aina, A., & May, S. (2022). The benefits of adding manual therapy to exercise therapy for improving pain and function in patients with knee or hip osteoarthritis: A systematic review with meta-analysis. Journal of Orthopaedic & Sports Physical Therapy, 52(10), 675–A13. https://doi.org/10.2519/jospt.2022.11062

  16. van den Ende, C. H. M., Minten, M. J. M., Leseman-Hoogenboom, M. M., van den Hoogen, F. H. J., den Broeder, A. A., Mahler, E. A. M., & Poortmans, P. M. P. (2020). Long-term efficacy of low-dose radiation therapy on symptoms in patients with knee and hand osteoarthritis. The Lancet Rheumatology, 2(1), e42–e49. https://doi.org/10.1016/S2665-9913(19)30096-7

  17. Zinser, W., Zinser, T., Sturmair, E., & Diemer, F. (2025). Pilot study on the clinical applicability of non-invasive joint distraction using the JD device for knee and hip osteoarthritis. Journal of Novel Physiotherapy and Physical Rehabilitation, 12(1), 006–012. https://doi.org/10.17352/2455-5487.000108

Injektionen

  1. Alazzeh, M. S., Naseh, H. A. M., Vasiliadis, A., Laupheimer, M., Kalifis, G., Al-Dolaymi, A., Macchiarola, L., & Marín Fermín, T. (2024). Platelet-rich plasma intra-articular knee injections from open preparation techniques do not pose a higher risk of joint infection: A systematic review of 91 randomized controlled trials and 5914 injections. Journal of Experimental Orthopaedics, 11(3). https://doi.org/10.1002/jeo2.70002

  2. Baltzer, A. W. A., Moser, C., Jansen, S. A., & Krauspe, R. (2009). Autologous conditioned serum is an effective treatment for knee osteoarthritis. Osteoarthritis and Cartilage, 17(2), 152–160. https://doi.org/10.1016/j.joca.2008.06.014

  3. Concoff, A., Sancheti, P., Niazi, F., Shaw, P., & Rosen, J. (2017). The efficacy of multiple versus single hyaluronic acid injections: A systematic review and meta-analysis. BMC Musculoskeletal Disorders, 18, 542. https://doi.org/10.1186/s12891-017-1897-2

  4. Hangody, L., Szody, R., Lukasik, P., et al. (2018). Intraarticular injection of a cross-linked sodium hyaluronate combined with triamcinolone hexacetonide to provide symptomatic relief of osteoarthritis of the knee. Cartilage, 9(3), 276–283. https://doi.org/10.1177/1947603517703732

  5. McLarnon, M., & Heron, N. (2021). Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: Systematic review and meta-analysis. BMC Musculoskeletal Disorders, 22, 550. https://doi.org/10.1186/s12891-021-04308-3

  6. Zhao, J., Huang, H., Liang, G., Zeng, L.-F., Yang, W., & Liu, J. (2020). Effects and safety of the combination of platelet-rich plasma and hyaluronic acid in the treatment of knee osteoarthritis: A systematic review and meta-analysis. BMC Musculoskeletal Disorders, 21, 224. https://doi.org/10.1186/s12891-020-03262-w

Medikamente

  1. da Costa, B. R., Pereira, T. V., Saadat, P., et al. (2021). Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: Network meta-analysis. BMJ, 375, n2321. https://doi.org/10.1136/bmj.n2321

  2. Machado, G. C., Maher, C. G., Ferreira, P. H., Pinheiro, M. B., Lin, C.-W. C., Day, R. O., McLachlan, A. J., & Ferreira, M. L. (2015). Efficacy and safety of paracetamol for spinal pain and osteoarthritis: Systematic review and meta-analysis of randomised placebo-controlled trials. BMJ, 350, h1225. https://doi.org/10.1136/bmj.h1225

  3. Osani, M. C., Lohmander, L. S., & Bannuru, R. R. (2021). Is there any role for opioids in the management of knee and hip osteoarthritis? A systematic review and meta-analysis. Arthritis Care & Research, 73(10), 1413–1424. https://doi.org/10.1002/acr.24363

  4. Persson, M. S. M., Stocks, J., Walsh, D. A., Doherty, M., & Zhang, W. (2018). The relative efficacy of topical non-steroidal anti-inflammatory drugs and capsaicin in osteoarthritis: A network meta-analysis of randomised controlled trials. Osteoarthritis and Cartilage, 26(12), 1575–1582. https://doi.org/10.1016/j.joca.2018.08.008

  5. Zeng, C., Wei, J., Persson, M. S. M., Sarmanova, A., Doherty, M., Xie, D., Wang, Y., Li, X., Li, J., Long, H., Lei, G., & Zhang, W. (2018). Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: A systematic review and network meta-analysis. British Journal of Sports Medicine, 52(10), 642–650. https://doi.org/10.1136/bjsports-2017-098043

Übergreifende Leitlinien

  1. Bannuru, R. R., Osani, M. C., Vaysbrot, E. E., et al. (2019). OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis and Cartilage, 27(11), 1578–1589. https://doi.org/10.1016/j.joca.2019.06.011

  2. Deutsche Gesellschaft für Orthopädie und Unfallchirurgie. (2024/2025). S3-Leitlinie Prävention und Therapie der Gonarthrose (AWMF-Registernummer 187-050). https://register.awmf.org/de/leitlinien/detail/187-050

  3. Kolasinski, S. L., Neogi, T., Hochberg, M. C., et al. (2020). 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis & Rheumatology, 72(2), 220–233. https://doi.org/10.1002/art.41142

  4. National Institute for Health and Care Excellence. (2022). Osteoarthritis in over 16s: Diagnosis and management (NICE Guideline NG226). https://www.nice.org.uk/guidance/ng226